AS Roma and Juventus lost on their domestic returns from midweek UEFA Champions League action as their miserable starts to the season continued. In England, frontrunners Liverpool and Chelsea fared better with wins while Valencia top the table on goal difference in Spain and Lazio, Udinese and champions Inter Milan share the lead in Italy.
Former Juventus coach Claudio Ranieri is poised to take over at AS Roma after Luciano Spalletti quit the Serie A side following their poor start to the season.
Barcelona and Atletico Madrid maintained their perfect records in La Liga while Premier League club Arsenal dropped points but returned to the top of the table.
Europa League favourites Manchester United secured a 1-1 draw on a threadbare pitch at Rostov, while Olympique Lyonnais beat AS Roma 4-2 helped by a fine individual goal from Nabil Fekir in their last 16, first leg ties on Thursday.
Manchester United and AS Roma will meet in the Champions League group stages.
Manchester United manager Alex Ferguson is expecting AS Roma to come looking for revenge in their Champions League tie on Tuesday.
Antonio Cassano scored his first AC Milan goal and Robinho struck twice to help the Serie A leaders end a run of two straight draws in a 4-0 home thrashing of Parma on Saturday.
Leaders Barcelona played out a second straight 0-0 draw in LaLiga after mid-table Getafe battled for a home point in a hard-fought game on Sunday.
'I'm very excited to be here. I'm very happy'
AS Roma moved to within four points of third-placed Lazio and a Champions League qualifying round berth after an exciting 5-2 home win against relegation-threatened Novara on Sunday.
AS Roma edged closer to a first ever league and cup double by limping into the Italian Cup final after a 1-0 defeat at Udinese in Wednesday's second leg tie.
Barcelona's Luis Suarez hit a brace and set up a double for a spritely Lionel Messi to score in his first start after injury in a rampant 6-1 Champions League victory over AS Roma on Tuesday.
2004 Champions League finalists Monaco were eliminated 2-1 on aggregate by Swiss side Basel.
Juventus striker Carlos Tevez scored a magnificent first-half goal, and later missed a penalty, as the runaway Serie A leaders won 1-0 at home to mid-table Genoa on Sunday.
Holders FC Barcelona have been placed in Group E, along with Bayer Leverkusen, AS Roma, Dinamo Zagreb.
AS Roma ended a five-match winless run against arch-rivals Lazio with a 2-0 win on Sunday which maintained their 100 percent record after four games in Serie A.
A round-up of the soccer matches played accross Europe over the weekend.
Brighton secured their second victory of the competition with a comfortable win at Ajax thanks to goals from Ansu Fati and Simon Adingra.
Liverpool will take on LASK, Union Saint-Gilloise and Toulouse in the Europa League group stage while debutants Brighton & Hove Albion will face Ajax Amsterdam and Olympique de Marseille following the draw on Friday.
AS Roma boosted their Serie A title challenge with a 1-0 win at Udinese on Tuesday amid controversy over whether Davide Astori's header had crossed the line for the game's only goal.
Bayer Leverkusen rallied with three second-half goals to beat AS Roma 3-1 in a Champions League Group B match on Tuesday.
AS Roma midfielder Daniele de Rossi received a three-match ban on Friday for an off-the-ball incident in last week's Champions League match against Shakhtar Donetsk.
Manchester United striker Wayne Rooney will captain the side for their Champions League game at AS Roma, manager Alex Ferguson said.
Chelsea came from behind to beat Crystal Palace 3-1 thanks to added time goals from Conor Gallagher and Enzo Fernandez.
AS Roma captain Francesco Totti, who has been at his hometown team his whole career, hinted for the first time on Tuesday that he could leave the club after a row with coach Claudio Ranieri.
Cristiano Ronaldo continued from where he left off in the early stages of the UEFA Champions League, adding to his goal tally as Real Madrid beat AS Roma 2-0 in their round of 16, first leg tie on Wednesday.
Goals by Marco Materazzi and Zlatan Ibrahimovic gave Serie A leaders Inter Milan a 2-0 victory over Messina on Sunday as they set a club record with their ninth straight league win.
AS Roma's lingering hopes of catching Serie A leaders Juventus were virtually extinguished after two stunning Pepe Reina saves kept them at bay and Jose Callejon's late goal handed third-placed Napoli a 1-0 home win on Sunday.
Arsenal sailed through the Europa League group stages, winning five of their six group matches and take on Sporting next, who overcame Denmark's FC Midtjylland in their playoff.
Champions Manchester United delivered a superb display to win 3-1 at title rivals Arsenal in the English Premier League on Sunday. AS Roma moved level on points with stuttering AC Milan in second spot in Italy's Serie A after a 2-1 win over bottom side Siena.
Inter Milan coach Jose Mourinho said on Tuesday he is not certain to stay at the Champions League finalists next season as his team prepared for the first part of their assault on an unprecedented Italian treble.
Chelsea secured top spot, above Barcelona, in Group A with a 2-0 home win over Levski Sofia.
Barcelona winger Raphinha secured a 1-0 win in LaLiga for the second straight week this time at Athletic Bilbao as his side tightened their grip on top spot.
AS Roma striker Francesco Totti will be aiming for another hat-trick at Atalanta on Sunday as speculation mounts about an Italy comeback, something Sampdoria's Antonio Cassano can only dream of.
New coach Luciano Spalletti failed to inspire AS Roma as they were held 1-1 at home by bottom club Verona on his debut on Sunday and Juventus notched their 10th Serie A win in a row by hammering Udinese 4-0 away.
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